I am a postdoctoral researcher at ToNIC - INSERM (Toulouse, France). I study and develop hybrid digital twin models to study coma and disorders of consciousness. My main goal is to understand the role of neuroinflammation in such conditions, with a particular focus on astrocyte and microglial responses in acute coma. My work involves data and image processing, mathematical modeling, asymptotic analysis, stochastic calculus, numerical (stochastic) simulations and machine learning techniques.
I have expertise in data and image processing, mathematical modeling, stochastic calculus, asymptotic analysis, numerical simulations and machine learning.
L. Zonca, A. Eschrichs, G. Patow, D. Manasova, Y. Sanz-Perl, J. Annen, O. Gosseries, S. Laureys, J.D. Sitt, G. Deco. Personalized models of disorders of consciousness reveal complementary roles of connectivity and local parametersin diagnosis and prognosis. Plos One 20(9): e0328219. (2025)
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L. Zonca, F.C. Bellier, G. Millior, P.Aymar, J. Visser, A. Rancillac, N. Rouach, D. Holcman. Unveiling thefunctional connectivity of astrocytic networks with AstroNet, a graph reconstruction algorithm coupled to image processing Communications Biology 8,114 (2025). https://doi.org/10.1038/s42003-024-07390-0
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E. Dossi*, L. Zonca*, H. Pivonkova, O. Chever, D. Hoclman, N. Rouach. Astroglial gap junctions strengthen hippocampal network activity by sustaining after-hyperpolarization via KCNQ channels, Cell Reports, 43:5, 114158 (2024) (* equal contribution)
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L. Zonca & D. Holcman.Escape from an attractor generated by recurrent exit and application tointerburst durations in neuronal networks, Physical Review Research, 3, 023115 (2021)
preprint article
L. Zonca & D. Holcman.Emergence and fragmentation of the alpha-band driven by neuronal network dynamics, PLOS Computational Biology 17(12): e1009639 (2021)
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L. Zonca & D. Holcman. Modeling bursting in neuronal networks using facilitation-depression and afterhyperpolarization, Communicationsin nonlinear science and numerical simulations, 94, 105555 (2021)
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Complete publication list
In agreement with the FAIR principles of openscience, I distribute all the codes I implement for my projects as open source:
- The codes from my PhD projects are available on zenodo and https://bionewmetrics.org/
- The AstroNet MATLAB toolbox is available at: https://github.com/louzonca/NetConstruct
- The personailzed DoC models and corresponded codes are available at: https://github.com/louzonca/DoC_models
